Picric acid (Carbazotic acid), a trinitrophenol. Formula, C6H3 (NO2)3. OH.
Preparation: Solutions in alcohol (or triturations).
While enjoying the society of gentlemen, the idea of marriage seemed unendurable. Low spirits (second and twelfth days). A great desire to be alone (eleventh day). Very irritable (after third dose, thirteenth day). Great indifference and lassitude (fourth day). Great indifference; lack of will-power to undertake anything (fourth day). Disinclination for mental or physical work; desire to sit still; aversion to talking or movement, with the headache (second day); dulness and indifference; disinclination to talk and study; takes no interest in surrounding things (third day). Can’t collect thoughts at all or study (fifth day). During the day could not keep my thoughts to study; I could read for a little time, then my mind would seem to be played out (sixth day). Prostration of mind after writing for a time (eighth day).
Vertigo. At 6 P.M. vertigo, with nausea, on least motion; at 9 P.M. vertigo and nausea, with the intense pain in frontal region and vertex; could not sit up; greatly aggravated by even raising the head (second day). Vertigo worse, in the evening (thirteenth day). Vertigo, on stooping or bending of the head and on lying down (eleventh day). Dizziness and vertigo, lasting half an hour, worse when rising up from sitting position, at 12 M. (thirteenth day). General Head. Head felt congested (eleventh day). Sensation of fullness and heaviness of the head, with disinclination for mental or physical work, at 12 noon; fullness and heaviness increased until 2 P.M., when it developed into a severe throbbing headache; worse on the left side, but chiefly in the left eye and occipital region; markedly aggravated by going upstairs, which causes an intense throbbing pain in the eyeball; headache relieved at 4 P.M. (second day); fullness and heaviness of the head, followed by throbbing pain in the eye and occiput (left), but not as marked as before (third day). Heavy (fullness) dull pressing pain in the head, as if full of blood (after nine hours). Fullness and heaviness of the head, with disinclination to do anything (after four hours); headache increases, and finally develops into an intense throbbing pain in left side of the head, chiefly in the eyeball and forehead, and extending backwards to occipital region; better from keeping quiet; worse from motion, and greatly aggravated by going upstairs. Heaviness of the head, alternating with a sensation of emptiness (after half an hour). Head feels heavy (first, second, and third days).
Head feels dull and heavy (after seven hours, twelfth day); (third day). Dull heavy feeling in the head (third day). Head feels as if falling forward (after four hours, fifth day).
Headache of a heavy blinding dizzy character, with great fullness; head feels as if it would burst open; head feels as if too small; pains mostly in the vertex and frontal regions; stooping aggravated the pains, and causes vertigo; headache comes on at 9 A.M., and steadily increases until I go to bed; scalp sensitive to touch; sore aching in infraorbital region (after one hour, fifth day). Dull general headache (seventh day). Dull headache; could not get to sleep until 2 o’clock, after going to bed at 9 (tenth day). Dull heavy headache, lasting all day, coming first on the right side, then spreading to the left (ninth day). Slight dull headache (ninth day. A peculiar dull continuous pain all over the head; aggravated by motion, turning the head, and stooping; relieved by lateral pressure upon the head (after seven hours and a half, fourth day). Dull pain diffused throughout the head (sixth day). Severe headache all day, aggravated on rising, better in open air (eleventh day).
Headache, which he never before had, was one of the most marked symptoms. Head much worse, in the evening; cannot study (sixth day); head somewhat affected, in the evening (seventh day).
Headache, with trembling, afternoon and evening (ninth day); headache, in the evening (tenth day). Headache (after first dose, twelfth day); continued (after third dose, twelfth day).
Headache, with head in the head (after first dose, thirteenth day). Headache slight, in the morning, probably in consequence of oversleeping (thirty-ninth day). Slight headache more or less all day, confined to the upper part of anterior and;middle lobes of brain, also above the eyes; the character of the pain is dull, with an occasional shoot of pain (ninth day). Not much headache in the forenoon; more severe in the afternoon (fourteenth day).
Slight headache for two days after taking the medicine. At 8 P.M.
full pressing sensation in the head, from within outwards, as if the head would fly apart; greatly aggravated by motion and by study (second day). At 9 P.M. severe pressing pain in the head, laterally, from within outwards, with sensation as if the frontal bones would split open; aggravated by turning the head, moving the eyes, or from the least motion (second day). Pains generally about the head, relieved by pressure (after ten hours). Felt well before taking the drug, but in a short time pain came in head, and exact repetition of previous symptoms (eighth day). Do not feel able to study on account of pain in head (third day). All the head pains ceased by bandaging the head tightly (fifth day).
Heavy throbbing pains in the head, extending from behind the ears forward;to the supraorbital notch, and thence downward into the eye, with the great soreness and lameness, especially on left side (fifth day). Burning along the coronal suture (after second dose, twelfth day). Head symptoms continued for several days after discontinuance of drug. Forehead. Dull headache in the front and right side of head, with heat in head and upper part of body (after two hours); in the evening pain in the head, with some thirst and heat, chiefly in the temples, and burning sensation in external ears (first day). At 7 P.M. dull steady frontal headache (with vertigo when rising and when walking), (second day). Dull heavy pain in frontal region, extending to the vertex, worse from motion, at 10 A.M.; at 1 P.M. headache worse, aggravated by the least motion, stooping, bowing the head, or rolling the eyes; at 5 P.M. intense pressing headache, as before (second day). Intense pain in frontal region and vertex, with vertigo and nausea, at 9 P.M. (second day). Dull sleepy pain in the forehead, with sour eructations (lasting an hour), at 3 P.M.
(second day). Dull heavy frontal headache, with great heaviness and weakness in small of back and limbs (fourth day). Slight frontal headache, with sickness at the stomach, as from a weight (third day). Headache confined to front part of head; shoots from outside to center, quite severe, lasting all the evening (twelfth day). In thirty minutes a dull pain in forehead and temples, worse on the right side (first, second, and third days); headache not so severe (sixth day). Slight frontal headache, extending to vertex, of a dull heavy tingling character, all of the evening (second day). Same kind of headache as usual in superior part of anterior lobes of brain (after third dose, third day). Headache in anterior and superior part of head, lasting all the evening (eighth day). Headache confined to back part of anterior and top of middle lobes of brain; pain dull, with an occasional throb (eleventh day). Temples. Beating of temporal arteries (first, second, third, twelfth, and thirteenth days). A disagreeable dull headache, severest over right temple, passing around occiput (after four hours, second day). Dull sleepy pain over left temple (after nine hours, fifth day). Sharp and severe pain in right temple, running to back of head (after twenty minutes); soon after it appeared in left temple, extending to suboccipital region; these pains lasted but a short time (first day). Same pains as yesterday, but more severe in left temple; lasted about an hour (after fifteen minutes, second day). Pain in left temple, sharp and neuralgic in character, disappearing in left and going to right temple; it alternated between the two temples, and was more severe than on the two preceding days (after five minutes, third day). Severe sharp intermitting pain in the left temple (after ten hours, sixth day). Sharp cutting pain in left temple, over a small transverse branch of the temporal artery (second day). The pain of the head have been changeable, alternating between right and left temple, sometimes occurring in center of forehead (third to seventh day). The pain in the temples increased, and also the pain in the forehead; all these pains extends over the eyebrow to the inner angle of right eye (after four hours, seventh day). Slight dull and throbbing pain in right temple (after thirty minutes, first day, and after one hour, second day). Pressing headache between the temples (after second dose, eleventh day); headache increased (after third dose, eleventh day). Vertex. Full heavy feeling in the vertex, at 8 A.M. (second day). Full feeling on top of head (tenth day). Full heavy headache in the vertex, worse when stooping and moving eyes (after four hours and a half, third day). Slight headache in top of head, soon after taking medicine (tenth day); same pain in vertex (eleventh day). The usual headache to-day more severe, in the afternoon (fifteenth day). More headache in the vertex, aggravated by studying and bending the head forward (after second dose, sixteenth day). No headache this morning, but during the night, when I awoke, I had considerable through the upper and back part of head; I have felt this several times during the day (sixteenth day). Headache, throbbing on top of head, aggravated by turning to lie on back, with the nausea (tenth day). Slight twinges of pain on top of head, at 9 P.M. (thirty- ninth day).
About 11 A.M. pain in vertex, with slight fever (second day).
Parietals and Occiput. Felt a slight dart of pain on right side of head, about the middle of the afternoon (fourteenth day).
Headache, mostly in right side, with occasionally a shooting pain through the temples from right to left side (seventh day). Pain in the right side of the head, running behind the ear (after two hours and a quarter). Contracted or squeezed sensation of left hemisphere of brain on going into open air, at 6.30 P.M. (second day). Dull pain in right lower occipital region, beginning at 11.15 A.M. and lasting till 12.30 P.M.; the pain came on gradually and as gradually subsided (third day). Pain in right lower occipital region, at 8 P.M., lasting about an hour, and at the same time a sensation as of a band passing along the right parietal eminence (fourth day). At 9.15 A.M. dull pain in right lower occipital region, which comes and goes at short intervals (fifth day). At 1 P.M. pain in lower right occipital region, coming on at intervals since 11 A.M. (eighth day). A dull pain began in right lower occipital region at 8 A.M. and continued two hours (ninth day); beginning about 4 P.M. and lasting until 10 P.M. (eighteenth day). Dull heavy throbbing and burning pains, commencing in occiput and extending forward to supraorbital foramen, and thence down into the eyes, which throb and feel sore to the touch (after ten hours). Pain in lower right occipital region again comes on, lasting about an hour (fourth day). At 6 P.M. pain in lower right occipital region, as though right side of cerebellum was loose; keeps throbbing; worse on walking; better while sitting quiet; passes off in about an hour (fourth day). In the evening, pain in the right and lower part of occiput (eighth day). Pain in right side and lower part of occiput, coming on about 4 P.M., finally extends upwards over towards the right supraorbital region, continuing about three hours (ninth day). In the afternoon, pain for a few minutes in right and lower side of occiput (tenth day). In the afternoon, pain in right and lower side of occiput (fourteenth day). Pain in lower and right side of occiput, in the evening; did not last more than half an hour (nineteenth day). Heavy pain in occipital region, extending down the neck and spine (after nine hours). Pain in back of head and neck (third day).
Bright yellow color of the sclerotic, skin, and urine (second morning). Eyes to-day markedly yellow, being stained by the acid (seventh day). Yesterday I observed a slight dryness of my eyes, and a slight tingling or smarting, worse by constant use and lamp light. This morning there was some thick acrid matter in the corners of my eyes, worse by constant use and lamp light (ninth day). On waking, and for an hour afterwards, eyes felt as though there were sticks in them; inflammation of eyes has partly subsided (eighteenth day); felt all the evening as though there were sticks in them (twentieth day). Sensation as if sand was in the eyes, with smarting pain and acrid tears (fourth day). Eyes feel dry, as if full of sand (seventh day). Eyes have felt throughout the proving as if dry, and inner surface of lids feel rough (tenth day). Awoke with sharp stinging pains in both eyes, at 7 A.M. (sixth day). Eyes feel sore (tenth day). Eyes feel worse on moving them, or turning them upwards (fifth day).
Gaslight hurts the eyes (after ten hours). Orbit. Pressure over both eyes, worse from studying and motion, better from sitting still (after eleven hours, eleventh day). Pain over right eye in supraorbital region, sharp and vibrating stopping a moment or so, and beginning again (lasted half an hour), (after five hours). Dull pain in the supraorbital region, coming from the occiput (after four hours), worse from movement and stooping (second day). Dull, heavy headache in supraorbital region as before (after six hours, eighth day). Slight pain in supraorbital region and in the back of the neck (after three hours and a half).
Severe aching pain in the left supraorbital notch, at 6 P.M.
(eighth day). Head feels disagreeable and sore, especially the supraorbital region, at 5 P.M. (second day). Dull pain in supraorbital region (sixth day). Supraorbital and frontal headache, more or less all day (thirteenth day). Throbbing over the right eye (after four hours, seventh day). Lids. Lids sore and slightly swollen (third day). Styes, with soreness and swelling of lids (fifth day). Margins of lids very red on waking (thirty-ninth day). Agglutination of eyelids, on waking, in the morning; had to “pick my eyes open” (seventeenth day). Great heaviness of the lids; can’t keep them open (fifth day). Heat in upper eyelids, with increased flow of lachrymal secretion (after second dose, thirteenth day). In the evening, heaviness of eyelids, with a little burning in the eyes (sixteenth day).
Heaviness of the lids (after ten hours). Lachrymation.
Lachrymation (fifth day); (after ten hours). Eyes watery; stinging pain in them (after four hours, fifth day). Conjunctiva.
Conjunctivitis (fifth day). Conjunctiva injected (after ten hours). Conjunctiva greatly inflamed, right eye is the worst; hard work to keep eyes open; makes eyes feel sticky to read; eyes better from washing in cold water and in cold air, worse in warm room (seventeenth day). Ball. Aching pain in the eyeballs, which feel sore; worse by moving them;;better by closing them and keeping quiet (second day). Eyeballs sore to touch, with photophobia (third day). Severe, sharp, shooting pain in center of the eye, extending back to occipital region; pain seemed to follow the course of the optic nerve (third day). Sore, painful sensation in the eyeball; pains in the eyes aggravated by strong light, and by turning the eye; cannot bear to look at a bright light (fifth day). Heavy, pressing, smarting, and burning pain in the eyeball, relieved by pressure (after ten hours). A shooting pain from right eyeball to right side of occiput, lasting but a few seconds (after ten minutes). Pupil. Dilated pupils (fifth and seventh days); (after ten hours); (fifth day). Vision. Sight dim and confused (tenth day). Have to bring objects close to the eyes to see them; seem to be looking through a veil; can see to read clearly only at one point, about five inches from the eyes (after ten hours). While reading, sight is blurred, seemingly caused by winking mucus over the pupils (sixteenth day). Everything seems blurred, as if looking through a fog or a thick veil; can read only with book about five inches from the eyes (fifth and seventh days). Air looks smoky (sixteenth day). Sparks before the eyes (after half an hour). Whirling of objects (after half an hour).
Ears began to burn and look puffy, with a sensation as if worms were crawling on them; these symptoms lasted two hours (after six hours). Burning sensation in external ears, with the headache (first day). Pain behind the right ear, running down right side of neck (after four hours, seventh day). Buzzing and hissing in the ears (after half an hour).
Bleeding of the nose (right nostril), with heat and congestion of the head (after six hours and a half); bleeding of right nostril again (after seven hours and a half, and fourteen hours). Nose filled with mucus; can breathe only through the mouth; relieved by going into open air (third and fourth days). Small furuncle in the left nostril. Stinging pain in right side of nose (after four hours, seventh day). Sensation as if something were pressing greatly on the bridge of the nose (fifth day).
Tingling sensation of lips (after thirty minutes, first day, after one hour, second day). Irregular dull pain in inferior maxillary bone, with beating in molar teeth (after two hours and a quarter).
Saliva white, frothy, and stringy; hangs in long strings to the floor (eighth day). Taste sour; bad taste in mouth (after four hours fifth day). Sour bitter taste in the mouth (third day).
Bitter taste in the mouth (second day). Bitter taste in mouth, with great thirst (twelfth day). Bad taste in mouth of gas (fourth day).