Picric acid (Carbazotic acid), a trinitrophenol. Formula, C6H3 (NO2)3. OH.
Preparation: Solutions in alcohol (or triturations).
While enjoying the society of gentlemen, the idea of marriage seemed unendurable. Low spirits (second and twelfth days). A great desire to be alone (eleventh day). Very irritable (after third dose, thirteenth day). Great indifference and lassitude (fourth day). Great indifference; lack of will-power to undertake anything (fourth day). Disinclination for mental or physical work; desire to sit still; aversion to talking or movement, with the headache (second day); dulness and indifference; disinclination to talk and study; takes no interest in surrounding things (third day). Can’t collect thoughts at all or study (fifth day). During the day could not keep my thoughts to study; I could read for a little time, then my mind would seem to be played out (sixth day). Prostration of mind after writing for a time (eighth day).
Vertigo. At 6 P.M. vertigo, with nausea, on least motion; at 9 P.M. vertigo and nausea, with the intense pain in frontal region and vertex; could not sit up; greatly aggravated by even raising the head (second day). Vertigo worse, in the evening (thirteenth day). Vertigo, on stooping or bending of the head and on lying down (eleventh day). Dizziness and vertigo, lasting half an hour, worse when rising up from sitting position, at 12 M. (thirteenth day). General Head. Head felt congested (eleventh day). Sensation of fullness and heaviness of the head, with disinclination for mental or physical work, at 12 noon; fullness and heaviness increased until 2 P.M., when it developed into a severe throbbing headache; worse on the left side, but chiefly in the left eye and occipital region; markedly aggravated by going upstairs, which causes an intense throbbing pain in the eyeball; headache relieved at 4 P.M. (second day); fullness and heaviness of the head, followed by throbbing pain in the eye and occiput (left), but not as marked as before (third day). Heavy (fullness) dull pressing pain in the head, as if full of blood (after nine hours). Fullness and heaviness of the head, with disinclination to do anything (after four hours); headache increases, and finally develops into an intense throbbing pain in left side of the head, chiefly in the eyeball and forehead, and extending backwards to occipital region; better from keeping quiet; worse from motion, and greatly aggravated by going upstairs. Heaviness of the head, alternating with a sensation of emptiness (after half an hour). Head feels heavy (first, second, and third days).
Head feels dull and heavy (after seven hours, twelfth day); (third day). Dull heavy feeling in the head (third day). Head feels as if falling forward (after four hours, fifth day).
Headache of a heavy blinding dizzy character, with great fullness; head feels as if it would burst open; head feels as if too small; pains mostly in the vertex and frontal regions; stooping aggravated the pains, and causes vertigo; headache comes on at 9 A.M., and steadily increases until I go to bed; scalp sensitive to touch; sore aching in infraorbital region (after one hour, fifth day). Dull general headache (seventh day). Dull headache; could not get to sleep until 2 o’clock, after going to bed at 9 (tenth day). Dull heavy headache, lasting all day, coming first on the right side, then spreading to the left (ninth day). Slight dull headache (ninth day. A peculiar dull continuous pain all over the head; aggravated by motion, turning the head, and stooping; relieved by lateral pressure upon the head (after seven hours and a half, fourth day). Dull pain diffused throughout the head (sixth day). Severe headache all day, aggravated on rising, better in open air (eleventh day).
Headache, which he never before had, was one of the most marked symptoms. Head much worse, in the evening; cannot study (sixth day); head somewhat affected, in the evening (seventh day).
Headache, with trembling, afternoon and evening (ninth day); headache, in the evening (tenth day). Headache (after first dose, twelfth day); continued (after third dose, twelfth day).
Headache, with head in the head (after first dose, thirteenth day). Headache slight, in the morning, probably in consequence of oversleeping (thirty-ninth day). Slight headache more or less all day, confined to the upper part of anterior and;middle lobes of brain, also above the eyes; the character of the pain is dull, with an occasional shoot of pain (ninth day). Not much headache in the forenoon; more severe in the afternoon (fourteenth day).
Slight headache for two days after taking the medicine. At 8 P.M.
full pressing sensation in the head, from within outwards, as if the head would fly apart; greatly aggravated by motion and by study (second day). At 9 P.M. severe pressing pain in the head, laterally, from within outwards, with sensation as if the frontal bones would split open; aggravated by turning the head, moving the eyes, or from the least motion (second day). Pains generally about the head, relieved by pressure (after ten hours). Felt well before taking the drug, but in a short time pain came in head, and exact repetition of previous symptoms (eighth day). Do not feel able to study on account of pain in head (third day). All the head pains ceased by bandaging the head tightly (fifth day).
Heavy throbbing pains in the head, extending from behind the ears forward;to the supraorbital notch, and thence downward into the eye, with the great soreness and lameness, especially on left side (fifth day). Burning along the coronal suture (after second dose, twelfth day). Head symptoms continued for several days after discontinuance of drug. Forehead. Dull headache in the front and right side of head, with heat in head and upper part of body (after two hours); in the evening pain in the head, with some thirst and heat, chiefly in the temples, and burning sensation in external ears (first day). At 7 P.M. dull steady frontal headache (with vertigo when rising and when walking), (second day). Dull heavy pain in frontal region, extending to the vertex, worse from motion, at 10 A.M.; at 1 P.M. headache worse, aggravated by the least motion, stooping, bowing the head, or rolling the eyes; at 5 P.M. intense pressing headache, as before (second day). Intense pain in frontal region and vertex, with vertigo and nausea, at 9 P.M. (second day). Dull sleepy pain in the forehead, with sour eructations (lasting an hour), at 3 P.M.
(second day). Dull heavy frontal headache, with great heaviness and weakness in small of back and limbs (fourth day). Slight frontal headache, with sickness at the stomach, as from a weight (third day). Headache confined to front part of head; shoots from outside to center, quite severe, lasting all the evening (twelfth day). In thirty minutes a dull pain in forehead and temples, worse on the right side (first, second, and third days); headache not so severe (sixth day). Slight frontal headache, extending to vertex, of a dull heavy tingling character, all of the evening (second day). Same kind of headache as usual in superior part of anterior lobes of brain (after third dose, third day). Headache in anterior and superior part of head, lasting all the evening (eighth day). Headache confined to back part of anterior and top of middle lobes of brain; pain dull, with an occasional throb (eleventh day). Temples. Beating of temporal arteries (first, second, third, twelfth, and thirteenth days). A disagreeable dull headache, severest over right temple, passing around occiput (after four hours, second day). Dull sleepy pain over left temple (after nine hours, fifth day). Sharp and severe pain in right temple, running to back of head (after twenty minutes); soon after it appeared in left temple, extending to suboccipital region; these pains lasted but a short time (first day). Same pains as yesterday, but more severe in left temple; lasted about an hour (after fifteen minutes, second day). Pain in left temple, sharp and neuralgic in character, disappearing in left and going to right temple; it alternated between the two temples, and was more severe than on the two preceding days (after five minutes, third day). Severe sharp intermitting pain in the left temple (after ten hours, sixth day). Sharp cutting pain in left temple, over a small transverse branch of the temporal artery (second day). The pain of the head have been changeable, alternating between right and left temple, sometimes occurring in center of forehead (third to seventh day). The pain in the temples increased, and also the pain in the forehead; all these pains extends over the eyebrow to the inner angle of right eye (after four hours, seventh day). Slight dull and throbbing pain in right temple (after thirty minutes, first day, and after one hour, second day). Pressing headache between the temples (after second dose, eleventh day); headache increased (after third dose, eleventh day). Vertex. Full heavy feeling in the vertex, at 8 A.M. (second day). Full feeling on top of head (tenth day). Full heavy headache in the vertex, worse when stooping and moving eyes (after four hours and a half, third day). Slight headache in top of head, soon after taking medicine (tenth day); same pain in vertex (eleventh day). The usual headache to-day more severe, in the afternoon (fifteenth day). More headache in the vertex, aggravated by studying and bending the head forward (after second dose, sixteenth day). No headache this morning, but during the night, when I awoke, I had considerable through the upper and back part of head; I have felt this several times during the day (sixteenth day). Headache, throbbing on top of head, aggravated by turning to lie on back, with the nausea (tenth day). Slight twinges of pain on top of head, at 9 P.M. (thirty- ninth day).